A Michael Addition-Induced Favorskii Rearrangement
نویسندگان
چکیده
منابع مشابه
Stereocontrolled synthesis of kelsoene by the homo-favorskii rearrangement.
[reaction: see text] (+/-)-Kelsoene (4) has been synthesized from 2,5-dihydroanisole in 16 steps in 12.5% overall yield. The key step involves a base-catalyzed reaction of gamma-keto tosylate (5), which effects a homo-Favorskii rearrangement to 16 as well as the corresponding intramolecular S(N)2 product 15 from the enolate of 5. Ketone 15 can efficiently be isomerized to cyclobutanone 17 havin...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1987
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.60.836